diff --git a/dev-python/grpclib/Manifest b/dev-python/grpclib/Manifest
deleted file mode 100644
index 689aaf9b93..0000000000
--- a/dev-python/grpclib/Manifest
+++ /dev/null
@@ -1,2 +0,0 @@
-DIST grpclib-0.4.2.gh.tar.gz 116997 BLAKE2B 8a3ad3022a4963f0539c212b66af615f4c1a73cec49801118af25ad141741aed692e16389687f690f885d9f85dc53a5e1b8208a5d8af111c2e50fdefef0684ce SHA512 a25ee2286431d294dd4b07b3ac34387608ca3dbabdf6d54a09b1a33fe66c75ba88f3f5e90160a55dc614871c93bc6ccfb884d149bbd624e13d792b44271b534f
-DIST grpclib-0.4.3.gh.tar.gz 106619 BLAKE2B 2ea5ae37c0f9e7c0aaf278922144135d536007d23a676298beb770c6f357887f383053a5c611a31cb55fb9dd7078a40c8ba0528425c039b473bd9f8cd022428a SHA512 2de4d95c26663eaf55e70cf1b2a0b5e44538b7543518702725616c6658d79a246996e4520cb1440f5910e3f353db7fb157812c57d42c2659c018c46ebff92224
diff --git a/dev-python/grpclib/files/grpclib-add_css_file.patch b/dev-python/grpclib/files/grpclib-add_css_file.patch
deleted file mode 100644
index 25243b9327..0000000000
--- a/dev-python/grpclib/files/grpclib-add_css_file.patch
+++ /dev/null
@@ -1,10 +0,0 @@
-diff --git a/docs/conf.py b/docs/conf.py
-index 7ccef26..766b77d 100644
---- a/docs/conf.py
-+++ b/docs/conf.py
-@@ -27,4 +27,4 @@ html_theme_options = {
- 
- 
- def setup(app):
--    app.add_stylesheet('style.css')
-+    app.add_css_file('style.css')
diff --git a/dev-python/grpclib/grpclib-0.4.2.ebuild b/dev-python/grpclib/grpclib-0.4.2.ebuild
deleted file mode 100644
index 3576b0e421..0000000000
--- a/dev-python/grpclib/grpclib-0.4.2.ebuild
+++ /dev/null
@@ -1,56 +0,0 @@
-# Copyright 1999-2022 Gentoo Authors
-# Distributed under the terms of the GNU General Public License v2
-
-EAPI=8
-
-DISTUTILS_USE_PEP517=setuptools
-PYTHON_COMPAT=( python3_{10..11} )
-
-inherit distutils-r1
-
-DESCRIPTION="Pure-Python gRPC implementation for asyncio"
-HOMEPAGE="https://github.com/vmagamedov/grpclib"
-if [[ ${PV} == 9999 ]]; then
-	inherit git-r3
-	EGIT_REPO_URI="https://github.com/vmagamedov/grpclib"
-else
-	MY_PV="${PV/_rc/rc}"
-	S="${WORKDIR}/${PN}-${MY_PV}"
-	SRC_URI="https://github.com/vmagamedov/${PN}/archive/refs/tags/v${MY_PV}.tar.gz -> ${P}.gh.tar.gz"
-	KEYWORDS="~amd64 ~x86"
-fi
-
-PATCHES=(
-	"${FILESDIR}/${PN}-add_css_file.patch"
-)
-
-LICENSE="BSD"
-SLOT="0"
-
-RDEPEND="
-	>=dev-python/h2-4.1.0[${PYTHON_USEDEP}]
-	>=dev-python/hpack-4.0.0[${PYTHON_USEDEP}]
-	>=dev-python/hyperframe-6.0.1[${PYTHON_USEDEP}]
-	>=dev-python/multidict-6.0.2[${PYTHON_USEDEP}]
-	>=dev-python/grpcio-tools-1.43.0[${PYTHON_USEDEP}]
-"
-BDEPEND="
-	test? (
-		dev-python/pytest-asyncio[${PYTHON_USEDEP}]
-		dev-python/async-timeout[${PYTHON_USEDEP}]
-		dev-python/googleapis-common-protos[${PYTHON_USEDEP}]
-		dev-python/Faker[${PYTHON_USEDEP}]
-	)
-"
-
-distutils_enable_tests pytest
-distutils_enable_sphinx docs \
-	'dev-python/sphinx-rtd-theme'
-
-python_test() {
-	[[ ${EPYTHON} == python3.10 ]] && local EPYTEST_DESELECT=(
-		# does not work in python3.10 due to the bug in ssl https://bugs.python.org/issue46067
-		'tests/test_client_channel.py::test_default_ssl_context'
-	)
-	epytest
-}
diff --git a/dev-python/grpclib/grpclib-0.4.3.ebuild b/dev-python/grpclib/grpclib-0.4.3.ebuild
deleted file mode 100644
index 398d964086..0000000000
--- a/dev-python/grpclib/grpclib-0.4.3.ebuild
+++ /dev/null
@@ -1,48 +0,0 @@
-# Copyright 1999-2020 Gentoo Authors
-# Distributed under the terms of the GNU General Public License v2
-
-EAPI=8
-
-DISTUTILS_USE_PEP517=setuptools
-PYTHON_COMPAT=( python3_{10..11} )
-
-inherit distutils-r1
-
-DESCRIPTION="Pure-Python gRPC implementation for asyncio"
-HOMEPAGE="https://github.com/vmagamedov/grpclib"
-if [[ ${PV} == 9999 ]]; then
-	inherit git-r3
-	EGIT_REPO_URI="https://github.com/vmagamedov/grpclib"
-else
-	MY_PV="${PV/_rc/rc}"
-	S="${WORKDIR}/${PN}-${MY_PV}"
-	SRC_URI="https://github.com/vmagamedov/${PN}/archive/refs/tags/v${MY_PV}.tar.gz -> ${P}.gh.tar.gz"
-	KEYWORDS="~amd64 ~x86"
-fi
-
-PATCHES=(
-	"${FILESDIR}/${PN}-add_css_file.patch"
-)
-
-LICENSE="BSD"
-SLOT="0"
-
-RDEPEND="
-	>=dev-python/h2-4.1.0[${PYTHON_USEDEP}]
-	>=dev-python/hpack-4.0.0[${PYTHON_USEDEP}]
-	>=dev-python/hyperframe-6.0.1[${PYTHON_USEDEP}]
-	>=dev-python/multidict-6.0.2[${PYTHON_USEDEP}]
-	>=dev-python/grpcio-tools-1.43.0[${PYTHON_USEDEP}]
-"
-BDEPEND="
-	test? (
-		dev-python/pytest-asyncio[${PYTHON_USEDEP}]
-		dev-python/async-timeout[${PYTHON_USEDEP}]
-		dev-python/googleapis-common-protos[${PYTHON_USEDEP}]
-		dev-python/Faker[${PYTHON_USEDEP}]
-	)
-"
-
-distutils_enable_tests pytest
-distutils_enable_sphinx docs \
-	'dev-python/sphinx-rtd-theme'
diff --git a/dev-python/grpclib/metadata.xml b/dev-python/grpclib/metadata.xml
deleted file mode 100644
index f63510012f..0000000000
--- a/dev-python/grpclib/metadata.xml
+++ /dev/null
@@ -1,13 +0,0 @@
-<?xml version="1.0" encoding="UTF-8"?>
-<!DOCTYPE pkgmetadata SYSTEM "https://www.gentoo.org/dtd/metadata.dtd">
-<pkgmetadata>
-  <maintainer type="person">
-    <email>antonin.riha@protonmail.com</email>
-    <name>Antonín Říha</name>
-  </maintainer>
-  <upstream>
-    <bugs-to>https://github.com/vmagamedov/grpclib/issues</bugs-to>
-    <remote-id type="pypi">grpclib</remote-id>
-    <remote-id type="github">vmagamedov/grpclib</remote-id>
-  </upstream>
-</pkgmetadata>
diff --git a/profiles/package.mask b/profiles/package.mask
index 8b6d74b73c..17741aa643 100644
--- a/profiles/package.mask
+++ b/profiles/package.mask
@@ -65,7 +65,6 @@ dev-python/sphinxext-opengraph
 # Dependencies dropped from ::gentoo
 # Removal 2024-07-07
 dev-python/betterproto
-dev-python/grpclib
 
 # Julien Roy <julien@jroy.ca> (2024-05-31)
 # Several versions out of date, needs a maintainer